Evolution of sex determining mechanisms in insects

Monika Hediger
Regina Perez
Caroline Henggeler


Nicole Meier
Andres Dübendorfer
Daniel Bopp

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          The existence of different sex-determining mechanisms in natural populations of Musca domestica makes the housefly a particularly suited system for studying evolutionary changes in sex determination pathways. We believe that these variations reflect minor changes in an otherwise well conserved pathway. By identifying the genes in the Musca pathway, we aim at an understanding of the principles of the underlying genetic control and, by comparison with sex determining genes in other species, of how such pathways evolve.

Dübendorfer, A., Hediger, M., Burghardt, G., and D. Bopp (2002). Musca domestica, a window on the evolution of sex-determining mechanisms in insects. Int. J. Dev. Biol. 46, 75-79. PubMed


Hediger, M., Burghardt, G., Siegenthaler, C., Buser, N., Hilfiker-Kleiner, D.,Dübendorfer, A., and D. Bopp (2004). Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex. Dev Genes Evol 214, 29-42. PubMed


Burghardt, G., Hediger, M., Siegenthaler, C., Moser, M., Dübendorfer, A., and D. Bopp (2005). The transformer2 gene in Musca domestica is required for selecting and maintaining the female pathway of development Dev Genes Evol. Epub. PubMed