Vertebrate Visual System Function
Vision is the primary sense of humans and the genetic control of its development and function is of both basic and medical research interest.
We have chosen the zebrafish (Danio rerio) as our main study object to understand various aspects of vision, focusing on the retina.
Our main approach is genetic, using induced mutations and transiently knockdown genetic models, and also transgenic animals. The effect of disrupted gene functions are assessed by a battery of histological, behavioral and electrophysiological techniques.
Since vertebrate retinas are conserved in structure and function, the transfer of knowledge to different vertebrates, including humans, is readily possible. Taking advantage of the cone dominated zebrafish retina, we are particularly interested in cone specific aspects of photopic (daylight) vision.
Current publications can also be seen at: