Publications

Prof. Konrad Basler

Cantù, Claudio; Pagella, Pierfrancesco; Shajiei, Tania D; Zimmerli, Dario; Valenta, Tomas; Hausmann, George; Basler, Konrad; Mitsiadis, Thimios A (2017). A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Science Signaling, 10(465):1.

Eder, Dominik; Aegerter, Christof; Basler, Konrad (2017). Forces controlling organ growth and size. Mechanisms of development, 144:53-61.

Toggweiler, Janine; Willecke, Maria; Basler, Konrad (2016). The transcription factor Ets21C drives tumor growth by cooperating with AP-1. Scientific Reports, 6:34725.

Valenta, Tomas; Degirmenci, Bahar; Moor, Andreas E; Herr, Patrick; Zimmerli, Dario; Moor, Matthias B; Hausmann, George; Cantù, Claudio; Aguet, Michel; Basler, Konrad (2016). Wnt ligands secreted by subepithelial mesenchymal cells are essential for the survival of intestinal stem cells and gut homeostasis. Cell Reports, 15:1-8.

Blyszczuk, Przemyslaw; Müller-Edenborn, Björn; Valenta, Tomas; Osto, Elena; Stellato, Mara; Behnke, Silvia; Glatz, Katharina; Basler, Konrad; Lüscher, Thomas F; Distler, Oliver; Eriksson, Urs; Kania, Gabriela (2016). Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. European Heart Journal:Epub ahead of print.

Heller, Davide; Hoppe, Andreas; Restrepo, Simon; Gatti, Lorenzo; Tournier, Alexander L; Tapon, Nicolas; Basler, Konrad; Mao, Yanlan (2016). EpiTools: An Open-Source Image Analysis Toolkit for Quantifying Epithelial Growth Dynamics. Developmental Cell, 36(1):103-116.

Mittag, Sonnhild; Valenta, Tomas; Weiske, Jörg; Bloch, Laura; Klingel, Susanne; Gradl, Dietmar; Wetzel, Franziska; Chen, Yuan; Petersen, Iver; Basler, Konrad; Huber, Otmar (2016). A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway. Cell Discovery, 2:15039.

Restrepo, Simon; Zartman, Jeremiah J; Basler, Konrad (2016). Cultivation and Live Imaging of Drosophila Imaginal Discs. Methods in Molecular Biology, 1478:203-213.

Jenny, Fabian H; Basler, Konrad (2016). Drosophila DDX3/Belle exerts its function outside of the Wnt/Wingless signaling pathway. PLoS ONE, 11(12):e0166862.

Restrepo, Simon; Basler, Konrad (2016). Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves. Nature Communications, 7:12450.

Riascos-Bernal, Dario F; Chinnasamy, Prameladevi; Cao, Longyue Lily; Dunaway, Charlene M; Valenta, Tomas; Basler, Konrad; Sibinga, Nicholas E S (2016). β-Catenin C-terminal signals suppress p53 and are essential for artery formation. Nature Communications, 7:12389.

Moor, Andreas E; Anderle, Pascale; Cantù, Claudio; Rodriguez, Patrick; Wiedemann, Norbert; Baruthio, Frédérique; Deka, Jürgen; André, Sylvie; Valenta, Tomas; Moor, Matthias B; Győrffy, Balázs; Barras, David; Delorenzi, Mauro; Basler, Konrad; Aguet, Michel (2015). BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer. EBioMedicine, 2(12):1932-1943.

Andersen, Ditte S; Colombani, Julien; Palmerini, Valentina; Chakrabandhu, Krittalak; Boone, Emilie; Röthlisberger, Michael; Toggweiler, Janine; Basler, Konrad; Mapelli, Marina; Hueber, Anne-Odile; Léopold, Pierre (2015). The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth. Nature, 522(7557):482-486.

Schertel, Claus; Albarca, Monica; Rockel-Bauer, Claudia; Kelley, Nicholas W; Bischof, Johannes; Hens, Korneel; van Nimwegen, Erik; Basler, Konrad; Deplancke, Bart (2015). A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Genome Research, 25(4):514-523.

Gillers, Benjamin S; Chiplunkar, Aditi; Aly, Haytham; Valenta, Tomas; Basler, Konrad; Christoffels, Vincent M; Efimov, Igor R; Boukens, Bastiaan J; Rentschler, Stacey (2015). Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties. Circulation Research, 116(3):398-406.

Jenny, Fabian Heinz; Basler, Konrad (2015). Powerful Drosophila screens that paved the wingless pathway. Fly, 8(4):218-225.

Draganova, Kalina; Zemke, Martina; Zurkirchen, Luis; Valenta, Tomas; Cantù, Claudio; Okoniewski, Michal; Schmid, Marie-Theres; Hoffmans, Raymond; Götz, Magdalena; Basler, Konrad; Sommer, Lukas (2015). Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells, 33(1):170-182.

Lebert, Dorothée; Louwagie, Mathilde; Goetze, Sandra; Picard, Guillaume; Ossola, Reto; Duquesne, Caroline; Basler, Konrad; Ferro, Myriam; Rinner, Oliver; Aebersold, Ruedi; Garin, Jérôme; Mouz, Nicolas; Brunner, Erich; Brun, Virginie (2015). DIGESTIF: A universal quality standard for the control of bottom-up proteomics experiments. Journal of Proteome Research, 14(2):787-803.

Gay, Max Hans-Peter; Valenta, Tomas; Herr, Patrick; Paratore-Hari, Lisette; Basler, Konrad; Sommer, Lukas (2015). Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biology, 13(24):online.

Zemke, Martina; Draganova, Kalina; Klug, Annika; Schöler, Anne; Zurkirchen, Luis; Gay, Max Hans-Peter; Cheng, Phil; Koseki, Haruhiko; Valenta, Tomas; Schübeler, Dirk; Basler, Konrad; Sommer, Lukas (2015). Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biology, 13:103.

Barbier de Reuille, Pierre; Routier-Kierzkowska, Anne-Lise; Kierzkowski, Daniel; Bassel, George W; Schüpbach, Thierry; Tauriello, Gerardo; Bajpai, Namrata; Strauss, Sören; Weber, Alain; Kiss, Annamaria; Burian, Agata; Hofhuis, Hugo; Sapala, Aleksandra; Lipowczan, Marcin; Heimlicher, Maria B; Robinson, Sarah; Bayer, Emmanuelle M; Basler, Konrad; Koumoutsakos, Petros; Roeder, Adrienne H K; Aegerter-Wilmsen, Tinri; Nakayama, Naomi; Tsiantis, Miltos; Hay, Angela; Kwiatkowska, Dorota; Xenarios, Ioannis; Kuhlemeier, Cris; Smith, Richard S (2015). MorphoGraphX: a platform for quantifying morphogenesis in 4D. eLife, 4(05864):online.

Meyer, S N; Amoyel, M; Bergantiños, C; de la Cova, C; Schertel, C; Basler, K; Johnston, L A (2014). An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science, 346(6214):1258236.

Reim, Gerlinde; Hruzova, Martina; Goetze, Sandra; Basler, Konrad (2014). Protection of Armadillo/β-Catenin by Armless, a Novel Positive Regulator of Wingless Signaling. PLoS Biology, 12(11):e1001988.

Cantù, Claudio; Zimmerli, Dario; Hausmann, George; Valenta, Tomas; Moor, Andreas; Aguet, Michel; Basler, Konrad (2014). Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes and Development, 28(17):1879-1884.

Qeli, Ermir; Omasits, Ulrich; Goetze, Sandra; Stekhoven, Daniel J; Frey, Juerg E; Basler, Konrad; Wollscheid, Bernd; Brunner, Erich; Ahrens, Christian H (2014). Improved prediction of peptide detectability for targeted proteomics using a rank-based algorithm and organism-specific data. Journal of Proteomics, 108:269-283.

Bischof, Johannes; Sheils, Emma M; Björklund, Mikael; Basler, Konrad (2014). Generation of a transgenic ORFeome library in Drosophila. Nature Protocols, 9(7):1607-1620.

Schilling, Sabine; Steiner, Sarah; Zimmerli, Dario; Basler, Konrad (2014). A regulatory receptor network directs the range and output of the Wingless signal. Development, 141(12):2483-2493.

Restrepo, Simon; Zartman, Jeremiah J; Basler, Konrad (2014). Coordination of patterning and growth by the Morphogen DPP. Current Biology, 24(6):R245-R255.

Marty, Florian; Rockel-Bauer, Claudia; Simigdala, Nikiana; Brunner, Erich; Basler, Konrad (2014). Large-scale imaginal disc sorting: A protocol for "omics"-approaches. Methods, 68(1):260-264.

Baillon, Ludovic; Basler, Konrad (2014). Reflections on cell competition: Growth, proliferation, morphogens and apoptosis. Seminars in Cell & Developmental Biology, 32:137-144.

Gerber, Florian; Marty, Florian; Eijkel, Gert B; Basler, Konrad; Brunner, Erich; Furrer, Reinhard; Heeren, Ron M A (2013). Multi order correction algorithms to remove image distortions from mass spectrometry imaging datasets. Analytical Chemistry, 85(21):10249-10254.

Pepperl, Julia; Reim, Gerlinde; Lüthi, Ursula; Kaech, Andres; Hausmann, George; Basler, Konrad (2013). Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling. Mechanisms of development, 130(9-10):493-505.

Bischof, Johannes; Björklund, Mikael; Furger, Edy; Schertel, Claus; Taipale, Jussi; Basler, Konrad (2013). A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila. Development, 140(11):2434-2442.

Cantù, Claudio; Valenta, Tomas; Hausmann, George; Vilain, Nathalie; Aguet, Michel; Basler, Konrad (2013). The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development, 140(11):2377-2386.

Schertel, Claus; Huang, Dashun; Björklund, Mikael; Bischof, Johannes; Yin, Dingzi; Li, Rongxia; Wu, Yi; Zeng, Rong; Wu, Jiarui; Taipale, Jussi; Song, Haiyun; Basler, Konrad (2013). Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Developmental Cell, 25(2):207-219.

Cantù, Claudio; Valenta, Tomas; Basler, Konrad (2013). A RING finger to wed TCF and β-catenin. EMBO Reports, 14(4):295-296.

Zartman, Jeremiah; Restrepo, Simon; Basler, Konrad (2013). A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development, 140(3):667-674.

Gafner, Lucia; Dalessi, Sascha; Escher, Eliane; Pyrowolakis, George; Bergmann, Sven; Basler, Konrad (2013). Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients. PLoS ONE, 8(8):e71224.

Hödl, Martina; Basler, Konrad (2012). Transcription in the absence of Histone H3.2 and H3K4 Methylation. Current Biology, 22(23):2253-2257.

Schertel, Claus; Rutishauser, Tobias; Förstemann, Klaus; Basler, Konrad (2012). Functional characterization of Drosophila microRNAs by a novel in vivo library. Genetics, 192(4):1543-52.

Herr, Patrick; Hausmann, George; Basler, Konrad (2012). WNT secretion and signalling in human disease. Trends in Molecular Medicine, 18(8):483-493.

Valenta, Tomas; Hausmann, George; Basler, Konrad (2012). The many faces and functions of β-catenin. EMBO Journal, 31(12):2714-2736.

Schwank, G; Yang, S F; Restrepo, S; Basler, K (2012). Comment on "Dynamics of dpp signaling and proliferation control". Science, 335(6067):401.

Aegerter-Wilmsen, Tinri; Heimlicher, Maria B; Smith, Alister C; de Reuille, Pierre Barbier; Smith, Richard S; Aegerter, Christof M; Basler, Konrad (2012). Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17):3221-3231.

Herr, P; Basler, K (2012). Porcupine-mediated lipidation is required for Wnt recognition by Wls. Developmental Biology, 361(2):392-402.

Schwank, G; Dalessi, S; Yang, S-F; Yagi, R; de Lachapelle, A M; Affolter, M; Bergmann, S; Basler, K (2011). Formation of the long range dpp morphogen gradient. PLoS Biology, 9(7):e1001111.

Schwank, G; Tauriello, G; Yagi, R; Kranz, E; Koumoutsakos, P; Basler, K (2011). Antagonistic growth regulation by dpp and fat drives uniform cell proliferation. Developmental Cell, 20(1):123-130.

Harterink, M; Port, F; Lorenowicz, M J; McGough, I J; Silhankova, M; Betist, M C; van Weering, J R T; van Heesbeen, R G H P; Middelkoop, T C; Basler, K; Cullen, P J; Korswagen, H C (2011). A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biology, 13(8):914-923.

Port, F; Hausmann, G; Basler, K (2011). A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. EMBO Reports, 12(11):1144-1152.

Affolter, M; Basler, K (2011). Cell biology. Cytonemes show their colors. Science, 332(6027):312-313.

Schilling, S; Willecke, M; Aegerter-Wilmsen, T; Cirpka, O A; Basler, K; von Mering, C (2011). Cell-sorting at the a/p boundary in the Drosophila wing primordium: a computational model to consolidate observed non-local effects of hh signaling. PLoS Computational Biology, 7(4):e1002025.

Gasnereau, I; Herr, P; Chia, P Z C; Basler, K; Gleeson, P A (2011). Identification of an endocytosis motif in an intracellular loop of Wntless, essential for its recycling and the control of Wnt signalling. Journal of Biological Chemistry, 286(50):43324-43333.

Restrepo, S; Basler, K (2011). Morphogen gradients: expand and repress. Current Biology, 21(19):R815-7.

Silhankova, M; Port, F; Harterink, M; Basler, K; Korswagen, H C (2010). Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. The EMBO Journal, 29(24):4094-4105.

Ahrens, C H; Brunner, E; Qeli, E; Basler, K; Aebersold, R (2010). Generating and navigating proteome maps using mass spectrometry. Nature Reviews. Molecular Cell Biology, 11(11):789-801.

Yagi, R; Mayer, F; Basler, K (2010). Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(37):16166-16171.

Ahrens, C H; Brunner, E; Basler, K (2010). Quantitative proteomics: a central technology for systems biology. Journal of Proteomics, 73(4):820-827.

Schwank, G; Basler, K (2010). Regulation of organ growth by morphogen gradients. Cold Spring Harbor Perspectives in Biology, 2(1):a001669.

Deka, J; Wiedemann, N; Anderle, P; Murphy-Seiler, F; Bultinck, J; Eyckerman, S; Stehle, J C; André, S; Vilain, N; Zilian, O; Robine, S; Delorenzi, M; Basler, K; Aguet, M (2010). Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Research, 70(16):6619-6628.

Song, H; Goetze, S; Bischof, J; Spichiger-Haeusermann, C; Kuster, M; Brunner, E; Basler, K (2010). Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. Genes and Development, 24(9):881-886.

Aegerter-Wilmsen, T; Smith, A C; Christen, A J; Aegerter, C M; Hafen, E; Basler, K (2010). Exploring the effects of mechanical feedback on epithelial topology. Development, 137(3):499-506.

Port, F; Basler, K (2010). Wnt trafficking: new insights into Wnt naturation, secretion and spreading. Traffic, 11(10):1265-1271.

Geuking, P; Narasimamurthy, R; Lemaitre, B; Basler, K; Leulier, F (2009). A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS ONE, 4(11):e7709.

Hamaratoglu, F; Basler, K; Affolter, M (2009). Confronting morphogen gradients: how important are they for growth? Science Signaling, 2(94):pe67.

Song, H; Spichiger-Haeusermann, C; Basler, K (2009). The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway. EMBO Reports, 10(10):1140-1146.

Hausmann, G; von Mering, C; Basler, K (2009). The hedgehog signaling pathway: where did it come from? PLoS Biology, 7(6):e1000146.

Mosimann, C; Hausmann, G; Basler, K (2009). Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nature Reviews. Molecular Cell Biology, 10(4):276-286.

Narasimamurthy, R; Geuking, P; Ingold, K; Willen, L; Schneider, P; Basler, K (2009). Structure-function analysis of Eiger, the Drosophila TNF homolog. Cell Research, 19(3):392-394.

Grobei, M A; Qeli, E; Brunner, E; Rehrauer, H; Zhang, R; Roschitzki, B; Basler, K; Ahrens, C H; Grossniklaus, U (2009). Deterministic protein inference for shotgun proteomics data provides new insights into Arabidopsis pollen development and function. Genome Research, 19(10):1786-1800.

Goetze, S; Qeli, E; Mosimann, C; Staes, A; Gerrits, B; Roschitzki, B; Mohanty, S; Niederer, E M; Laczko, E; Timmerman, E; Lange, V; Hafen, E; Aebersold, R; Vandekerckhove, J; Basler, K; Ahrens, C H; Gevaert, K; Brunner, E (2009). Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biology, 7(11):e1000236.

Kessler, R; Hausmann, G; Basler, K (2009). The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3. Mechanisms of Development, 126(8-9):752-759.

Mosimann, C; Hausmann, G; Basler, K (2009). The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mechanisms of Development, 126(5-6):394-405.

Hödl, M; Basler, K (2009). Transcription in the absence of histone H3.3. Current Biology, 19(14):1221-1226.

Schwank, G; Restrepo, S; Basler, K (2008). Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development, 135(24):4003-4013.

Affolter, M; Pyrowolakis, G; Weiss, A; Basler, K (2008). Signal-induced repression: the exception or the rule in developmental signaling? Developmental Cell, 15(1):11-22.

Katanaev, V L; Solis, G P; Hausmann, G; Buestorf, S; Katanayeva, N; Schrock, Y; Stuermer, C A O; Basler, K (2008). Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. The EMBO Journal, 27(3):509-521.

Bischof, J; Basler, K (2008). Recombinases and their use in gene activation, gene inactivation, and transgenesis. In: Dahmann, C. Drosophila : methods and protocols. Totowa, N.J., US: Springer, 175-195.

Port, F; Kuster, M; Herr, P; Furger, E; Bänziger, C; Hausmann, G; Basler, K (2008). Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nature Cell Biology, 10(2):178-185.

Hausmann, G; Bänziger, C; Basler, K (2007). Helping Wingless take flight: how WNT proteins are secreted. Nature Reviews. Molecular Cell Biology, 8(4):331-336.

Affolter, M; Basler, K (2007). The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nature Reviews. Genetics, 8(9):663-674.

Bänziger, C; Soldini, D; Schütt, C; Zipperlen, P; Hausmann, G; Basler, K (2006). Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell, 125(3):509-522.

Mosimann, C; Hausmann, G; Basler, K (2006). Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell, 125(2):327-341.

Geuking, Peter; Narasimamurthy, Rajesh; Basler, Konrad (2005). A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics, 171(4):1683-1694.

Städeli, R; Basler, K (2005). Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mechanisms of Development, 122(11):1171-1182.

Hoffmans, R; Städeli, R; Basler, K (2005). Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Current Biology, 15(13):1207-1211.

Zipperlen, P; Nairz, K; Rimann, I; Basler, K; Hafen, E; Hengartner, M; Hajnal, A (2005). A universal method for automated gene mapping. Genome Biology, 6(2):R19.

Hoffmans, R; Basler, K (2004). Identification and in vivo role of the Armadillo-Legless interaction. Development, 131(17):4393-4400.

Pyrowolakis, G; Hartmann, B; Müller, B; Basler, K; Affolter, M (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Developmental Cell, 7(2):229-240.

Scholz, N; Basler, K; Saur, P; Burchardi, H; Felder, S (2004). Outcome prediction in critical care: physicians' prognoses vs. scoring systems. European Journal of Anaesthesiology : EJA, 21(8):606-611.

Moreno, E; Basler, K (2004). dMyc transforms cells into super-competitors. Cell, 117(1):117-129.

Nairz, K; Zipperlen, P; Dearolf, C; Basler, K; Hafen, E (2004). A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Genome Biology, 5(10):R83.

Schweizer, L; Nellen, D; Basler, K (2003). Requirement for Pangolin/dTCF in Drosophila Wingless signaling. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(10):5846-5851.

Müller, B; Hartmann, B; Pyrowolakis, G; Affolter, M; Basler, K (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell, 113(2):221-233.

Végh, M; Basler, K (2003). A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics, 163(4):1427-1438.

Moreno, E; Basler, K; Morata, G (2002). Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature, 416(6882):755-759.

Gerlitz, O; Nellen, D; Ottiger, M; Basler, K (2002). A screen for genes expressed in Drosophila imaginal discs. International Journal of Developmental Biology, 46(1):173-176.

Moreno, E; Yan, M; Basler, K (2002). Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Current Biology, 12(14):1263-1268.

Ma, Y; Erkner, A; Gong, R; Yao, S; Taipale, J; Basler, K; Beachy, P A (2002). Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell, 111(1):63-75.

Bellotto, M; Bopp, D; Senti, K A; Burke, R; Deak, P; Maroy, P; Dickson, B J; Basler, K; Hafen, E (2002). Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. International Journal of Developmental Biology, 41(1):149-157.

Gerlitz, O; Basler, K (2002). Wingful, an extracellular feedback inhibitor of wingless. Genes and Development, 16(9):1055-1059.

Kramps, T; Peter, O; Brunner, E; Nellen, D; Froesch, B; Chatterjee, S; Murone, M; Züllig, S; Basler, K (2002). Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell, 109(1):47-60.

Hasson, P; Müller, B; Basler, K; Paroush, Z (2001). Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. The EMBO Journal, 20(20):5725-5736.

Chamoun, Z; Mann, R K; Nellen, D; von Kessler, D P; Bellotto, M; Beachy, P A; Basler, K (2001). Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science, 393(5537):2080-2084.

Méthot, N; Basler, K (2001). An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development, 128(5):733-742.

Sivasankaran, R; Vigano, M A; Müller, B; Affolter, M; Basler, K (2000). Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker. The EMBO Journal, 19(22):6162-6172.

Marty, T; Müller, B; Basler, K; Affolter, M (2000). Schnurri mediates Dpp-dependent repression of brinker transcription. Nature Cell Biology, 2(10):745-749.

Méthot, N; Basler, K (2000). Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development, 127(18):4001-4010.

Müller, B; Basler, K (2000). The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites. Development, 127(14):2999-3007.

Sivasankaran, R; Calleja, M; Morata, G; Basler, K (2000). The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Mechanisms of Development, 91(1-2):427-431.

Dahmann, C; Basler, K (2000). Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary. Cell, 100(4):411-422.

Burke, R; Nellen, D; Bellotto, M; Hafen, E; Senti, K A; Dickson, B J; Basler, K (1999). Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell, 99(7):803-815.

Dahmann, C; Basler, K (1999). Compartment boundaries: at the edge of development. Trends in Genetics, 15(8):320-326.

Morata, G; Basler, K (1999). Cells in search of a signal. Nature Cell Biology, 1(3):E60-E61.

Méthot, N; Basler, K (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell, 96(6):819-831.

Brunner, E; Brunner, D; Fu, W; Hafen, E; Basler, K (1999). The dominant mutation Glazed is a gain-of-function allele of wingless that, similar to loss of APC, interferes with normal eye development. Developmental Biology, 206(2):178-188.

von Mering, C; Basler, K (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Current Biology, 9(22):1319-1322.

Schweizer, L; Basler, K (1998). Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. Mechanisms of Development, 78(1-2):141-151.

Burke, R; Basler, K (1997). Hedgehog signaling in Drosophila eye and limb development - conserved machinery, divergent roles? Current Opinion in Neurobiology, 7(1):55-61.

Zecca, M; Basler, K; Struhl, G (1996). Direct and long-range action of a wingless morphogen gradient. Cell, 87(5):833-844.

Burke, R; Basler, K (1996). Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of Dpp signaling. Developmental Biology, 179(2):360-368.

Burke, R; Basler, K (1996). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development, 122(7):2261-2269.

Domínguez, M; Brunner, M; Hafen, E; Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science, 272(5268):1621-1625.

Nellen, D; Burke, R; Struhl, G; Basler, K (1996). Direct and long-range action of a DPP morphogen gradient. Cell, 85(3):357-368.

Zecca, M; Basler, K; Struhl, G (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development, 121(8):2265-2278.

Grieder, N C; Nellen, D; Burke, R; Basler, K; Affolter, M (1995). Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell, 81(5):791-800.

Ruberte, E; Marty, T; Nellen, D; Affolter, M; Basler, K (1995). An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell, 80(6):889-897.

Affolter, M; Nellen, D; Nussbaumer, U; Basler, K (1994). Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis. Development, 120(11):3105-3117.

Nellen, D; Affolter, M; Basler, K (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell, 78(2):225-237.

Basler, K; Edlund, T; Jessell, T M; Yamada, T (1993). Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell, 73(4):687-702.

Struhl, G; Basler, K (1993). Organizing activity of wingless protein in Drosophila. Cell, 72(4):527-540.

Dambly-Chaudière, C; Jamet, E; Burri, M; Bopp, D; Basler, K; Hafen, E; Dumont, N; Spielmann, P; Ghysen, A; Noll, M (1992). The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila. Cell, 69(1):159-172.

Basler, K; Christen, B; Hafen, E (1991). Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell, 64(6):1069-1081.

Basler, K; Oesch, B; Scott, M; Westaway, D; Wälchli, M; Groth, D F; McKinley, M P; Prusiner, S B; Weissmann, C (1986). Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell, 46(3):417-428.