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Single cell systems biology of cancer
Our lab develops experimental and computational methods to unravel regulatory systems on the single-cell level that underlie cancer development. Tumors are a tissue disease: A tumor is an assembly of a myriad of cancer cell clones and their differentiation continua and also includes different types of normal cells. The regulatory circuits of each of these cells are coupled to inter-cellular regulatory systems that rely on cell-to-cell communication and spatial features. The intricate interplay of these coupled control systems has a strong influence on tumor development and ultimately disease progression. Our group’s goal is to develop methods based on CyTOF mass cytometry to quantitatively analyze trans-cellular circuits. Based on the mass cytometry data we model and analyze how complex cell phenotypes in tumors are controlled. Our hope is that this will enable targeted modulation that interferes with the hallmarks of cancer and tumor development.
Tags: Imaging mass cytometry, CyTOF, network analysis, systems biology of cancer, tumor biology.
|1999-2001:||Vordiplom (Biochemistry), University of Bayreuth|
|2001-2004:||Diplom (Biochemistry), ETH Zurich|
|2004-2008:||Ph.D. Systems Biology (ETH Zurich, Lab of Ruedi Aebersold)|
|2008-2009:||Postdoc (ETH Zurich, Lab of Ruedi Aebersold)|
|2009-2012:||Postdoc (Stanford University, Lab of Garry P. Nolan)|
|since 2013||SNSF Assistant Professor, IMLS, University of Zurich, Switzerland|