Publications

2012

Jason Mercer, Berend Snijder, Raphael Sacher, Christine Burkard, Christopher Karl Ernst Bleck, Henning Stahlberg, Lucas Pelkmans, and Ari Helenius. 2012. "RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection." Cell Reports. doi:10.1016/j.celrep.2012.09.003 pdf

Berend Snijder, Raphael Sacher, Pauli Rämö, Prisca Liberali, Karin Mench, Nina Wolfrum, Laura Burleigh, Cameron C. Scott, Monique H. Verheije, Jason Mercer, Stefan Moese, Thomas Heger, Kristina Theusner, Andreas Jurgeit, David Lamparter, Giuseppe Balistreri, Mario Schelhaas, Cornelis A. M. De Haan, Varpu Marjomäki, Timo Hyypiä, Peter J. M. Rottier, Beate Sodeik, Mark Marsh, Jean Gruenberg, Ali Amara, Urs Greber, Ari Helenius, and Lucas Pelkmans. 2012. "Single-cell analysis of population context advances RNAi screening at multiple levels. " Molecular Systems Biology 8 Article number: 579 doi:10.1038/msb.2012.9 pdf

2011

Snijder B, Pelkmans L. (2011) . "Origins of regulated cell-to-cell variability." Nat Rev Mol Cell Biol. 12(2):119-25. pdf

2009

Rämö P, Sacher R, Snijder B, Begemann B, Pelkmans L. "CellClassifier: supervised learning of cellular phenotypes." Bioinformatics. 2009 Nov 15;25(22):3028-30. pdf

Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L. "Population context determines cell-to-cell variability in endocytosis and virus infection." Nature. 2009 Sep 24;461(7263):520-3. pdf

Pelkmans L. "Systems biology of virus infection in mammalian cells". Curr Opin Microbiol. 2009 Aug;12(4):429-31. pdf

2008

Sacher R, Stergiou L, Pelkmans L. "Lessons from genetics: interpreting complex phenotypes in RNAi screens." Curr Opin Cell Biol. 2008 Aug;20(4):483-9. pdf

Liberali P, Rämö P, Pelkmans L. "Protein kinases: starting a molecular systems view of endocytosis." Annu Rev Cell Dev Biol. 2008;24:501-23. pdf

2006

Bauer M, Pelkmans L. "A new paradigm of membrane-organizing and -shaping scaffolds." FEBS Lett. 2006 Oct 9; 580(23):5559-64. pdf

Damm EM, Pelkmans L. "Systems biology of virus entry in mammalian cells." Cell Microbiol. 2006 Aug;8(8):1219-27. pdf

2005

Tagawa A, Mezzacasa A, Hayer A, Longatti A, Pelkmans L, Helenius A. "Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters." J Cell Biol. 2005 Aug 29;170(5):769-79. pdf

Pelkmans L. "Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses." Biochim Biophys Acta. 2005 Dec 30;1746(3):295-304. pdf

Pelkmans L, Zerial M. "Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae." Nature. 2005 Jul 7;436(7047):128-33. pdf

Pelkmans L. "Viruses as probes for systems analysis of cellular signaling, cytoskeleton reorganization and endocytosis." Curr Opin Microbiol. 2005 Jun;8(3):331-7. pdf

Pelkmans L, Fava E, Grabner H, Hannus M, Habermann B, Krausz E, Zerial M. "Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis." Nature. 2005 Jul 7;436(7047):78-86. pdf

Damm EM, Pelkmans L, Kartenbeck J, Mezzacasa A, Kurzchalia T, Helenius A. "Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae." pdf

2004

Pelkmans L, Bürli T, Zerial M, Helenius A. "Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic." Cell. 2004 Sep 17;118(6):767-80. pdf

Pietiäinen V, Marjomäki V, Upla P, Pelkmans L, Helenius A, Hyypiä T. "Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events." Mol Biol Cell. 2004 Nov;15(11):4911-25. pdf

Miaczynska M, Pelkmans L, Zerial M. "Not just a sink: endosomes in control of signal transduction." Curr Opin Cell Biol. 2004 Aug;16(4):400-6. pdf

2003

Pelkmans L, Helenius A. "Insider information: what viruses tell us about endocytosis." Curr Opin Cell Biol. 2003 Aug; 15(4):414-22. pdf

2002

Pelkmans L, Helenius A. "Endocytosis via caveolae." Traffic. 2002 May;3(5):311-20. pdf

Pelkmans L, Püntener D, Helenius A. "Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae." Science. 2002 Apr 19;296(5567):535-9. pdf

2001

Pelkmans L, Kartenbeck J, Helenius A. "Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular transport pathway to the ER." Nat Cell Biol. 2001 May;3(5):473-83. pdf

before 2001

Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P. "Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles." Biochem J. 2000 Mar 15;346 Pt 3:593-601. pdf

Pelkmans L, Helenius A. "Expression of antibody interferes with disulfide bond formation and intracellular transport of antigen in the secretory pathway." J Biol Chem. 1999 May 14;274(20):14495-9. pdf