Adenovirus Image Gallery

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Adenovirus (Ad) model Ad2 structure
Ad2 structure
EM of negatively stained Ad2
EM of negatively stained Ad2
         
Fluorophore-labeled Ad2 Ad structural polypeptides
Ad structural polypeptides
FITC-labeled Ad2
FITC-labeled Ad2
Texas red (TR)-labeled Ad2
Texas red (TR)-labeled Ad2
         
Model of Adenovirus entry Schematic view
Schematic view
HeLa cell infected with Ad2 for 60 min (EM)
HeLa cell infected with
Ad2 for 60 min (EM)
         
Surface-attached Adenovirus Surface-bound Ad2 (EM)
Surface-bound Ad2 (EM)
Texas red labeled Ad2 on HeLa cells
Texas red labeled Ad2 on HeLa cells
 
         
Endocytosis EM's of Ad2 in coated pits, coated and uncoated vesicles EM's of Ad2 in coated pits, coated and uncoated vesicles EM's of Ad2 in coated pits, coated and uncoated vesicles Fiber release from incoming Ad2
Fiber release from incoming Ad2
EM's of Ad2 in coated pits, coated and uncoated vesicles
 
         
Escape from endosomes wtAd2 (EM)
wtAd2 (EM)
wtAd2 +
wtAd2 +
nocodazole (EM)
Ad2-ts1 (EM)
Ad2-ts1 (EM)
Ad2-ts1 blow up (EM)
Ad2-ts1 blow up (EM)
  No virus (EM)
No virus (EM)
Little degradation of incoming wtAd2
Little degradation
of incoming wtAd2
Entry and degradation of Ad2-ts1
Entry and degradation
of Ad2-ts1
         
Microtubule (MT)-dependent nuclear targeting Ad2 enrichment near MTOC (CLSM)
Ad2 enrichment near MTOC (CLSM)
Ad2 near microtubules (CLSM and EM) Ad2 near microtubules (CLSM and EM) MTs are involved in nuclear targeting
MTs are involved in nuclear targeting
Ad2 near microtubules (CLSM and EM)
 
         
Virus-nuclear pore complex (NPC) association and capsid disassembly Ad2 associated with NPCs (EMs) Ad2 associated with NPCs (EMs) Model of NPC-dependent capsid disassembly
Model of NPC-dependent capsid disassembly
Ad2 associated with NPCs (EMs)
         
Nuclear import of Ad2-DNA through the NPC Capsid and DNA are dissociated
Capsid and DNA are dissociated
Nuclear import of virus DNA
Nuclear import of virus DNA (FISH assay)
Model of NPC-dependent nuclear DNA import
Model of NPC-dependent nuclear DNA import