Citation Counts see Google Scholar Citations


Loughlin FE, Lukavsky PJ, Kazeeva T, Reber S, Hock EM, Colombo M, Von Schroetter C, Pauli P, Cléry A, Mühlemann O, Polymenidou M, Ruepp MD, Allain FH. (2018) The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol Cell. DOI:10.1016/j.molcel.2018.11.012. Pubmed link


Laferrière  F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock E-M, Wagner U, Afroz T, Boersema P J, Barmettler G, Foti S C, Asi Y T, Isaacs A M, Al-Amoudi A, Lewis A, Stahlberg  H, Ravits J, De Giorgi F, Ichas F, Bezard  E, Picotti P, Lashley T, Polymenidou  M. (2018) TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates. Nature Neurosc. DOI:10.1038/s41593-018-0294-y Nature Neuroscience


Jawaid A, Woldemichael BT, Kremer EA, Lafferriere F, Gaur N, Afroz T, Polymenidou M, Mansuy IM. (2018) Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis. Mol Neurobiol. DOI:10.1007/s12035-018-1314-3 Pubmed link


Hock EM, Maniecka Z, Hruska-Plochan M, Reber S, Laferrière F, Sahadevan M.K. S, Ederle H, Gittings L, Pelkmans L, Dupuis L, Lashley T, Ruepp M-D, Dormann D, Polymenidou M. (2018) Hypertonic stress causes cytoplasmic translocation of neural, but not astrocytic, FUS due to impaired transportin function. Cell Reports. DOI: Cell Reports


Polymenidou M. (2018) The RNA face of phase separation. Science. DOI:10.1126/science.aat8020 Science


Beynaems S, Alberti S, Fawzi N.L., Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. (2018) Protein phase separation: a new phase in Cell Biology. Trends in Cell Biology. DOI:10.1016/j.tcb.2018.02.004 Trends in Cell Biology


Foglieni C, Papin S, Salvadè A, Afroz T, Pinton S, Pedrioli G, Ulrich G, Polymenidou M & Paganetti P. (2017) Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins. Scientific Reports.DOI: 10.1038/s41598-017-14459-w Scientific Reports


Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy L A.B., Laferriere F, Maniecka Z, Plückthun A, Mittl P, Paganetti P, Allain F H.T& Polymenidou M. (2017) Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nature Communications. DOI: 10.1038/s41467-017-00062-0 2017 Nature Communications (PDF, 4805 KB) (PDF, 4805 KB)


Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.(2017) Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein. PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017 Pubmed link


Polymenidou M, Cleveland DW.(2017) Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med. 2017 Jan 6. pii: a024133. doi: 10.1101/cshperspect.a024133 Pubmed link


Hock EM, Polymenidou M (2016), Prion-like propagation as a pathogenic principle in frontotemporal dementia. J Neurochem. 2016 Aug;138 Suppl 1:163-83. doi: 10.1111/jnc.13668. Review. Pubmed link


Hruska-Plochan M, Li B, Diego K, Kruetzfeldt J, Landmesser U, Aguzzi A and  Polymenidou M (2015) New and emerging roles of small RNAs in neurodegeneration, muscle and inflammatory diseases, Swiss Medical Weekly, 2015;145:w14192. Swiss Medical Weekly link


Mitchell JC, Constable R, So E, Vance C, Scotter E, Glover L, Hortobagyi T, Arnold ES, Ling SC, McAlonis M, Da Cruz S,  Polymenidou M, Tessarolo L, Cleveland DW, Shaw CE (2015) Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS Acta Neuropathol Commun. 10.1186/s40478-015-0212-4. Pubmed link


Maniecka Z, Polymenidou M (2015) From nucleation to widespread propagation: A prion-like concept for ALS Virus Res 10.1016/j.virusres.2014.12.032. Pubmed link


Laferriere F, Polymenidou M (2015) Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis Swiss Med Wkly. 2015;145:w14054 Pubmed link


Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li  HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling S-C, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu X-D, Bennett CF, Cleveland DW, Ravits J (2013) Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration PNAS, 110, 47, E4530-39 2013 PNAS(2)  (PDF, 1478 KB)


Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTLD through disrupted RNA or protein homeostasis, Neuron, 79, 416-38 Pubmed link


Arnold ES, Ling S-C, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, DaCruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW (2013) ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 PNAS  110, 8, E736-45 2013 PNAS(1) (PDF, 2117 KB)



Baral PK, Wieland B, Swayampakula M, Polymenidou M, Rahman MH, Kav NNV, Aguzzi A, James MNG (2012) Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1 Acta Crystal Section D, 68, 1501-12Pubmed link  


Lagier-Tourenne C*, Polymenidou M*, Hutt KR*, Vu AQ, Clutario K, Baughn M, Huelga SC, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW and Yeo GW (2012) Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs, Nature Neurosc, 15, 1488-97 [*equal contribution] 2012 Nature Neurosci (PDF, 2740 KB)


Polymenidou M, Cleveland DW (2012) Prion-like spread of protein aggregates in neurodegeneration Journal of Exp Med, 209, 889-93 2012 J Exp Med (PDF, 1194 KB)


Polymenidou M*, Lagier-Tourenne C*, Hutt KR*, Bennett CF, Yeo GW, Cleveland DW (2012) Misregulated RNA processing in Amyotrophic Lateral Sclerosis Brain Res, Mar 3 [*equal contribution] 2012 Brain Res (PDF, 674 KB)


Baral PK, Wieland B, Swayampakula M, Polymenidou M, Aguzzi A, Kav NNV, James MNG (2011) Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody Acta Crystal Section F, 10, 1211-13  2011 Acta Crystal (PDF, 210 KB)


Polymenidou M, Cleveland DW (2011) The Seeds of Neurodegeneration: Prion-like Spreading in ALS Cell, 147, 498-508 2011 Cell (PDF, 416 KB)


Polymenidou M*, Lagier-Tourenne C*, Hutt KR*, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 Nature Neurosc, 14, 459–468 [*equal contribution] 2011 Nature Neurosci (PDF, 3985 KB)


Hafner-Bratkovič  I, Bester R, Pristovšek P, Gaedtke L, Veranič P, Gašperšič J, Manček-Keber M, Avbelj M, Polymenidou M, Julius C, Aguzzi A, Vorberg I, Jerala R (2011) Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion Journal of Biol Chem, 286, 12149-56 2011 J Biol Chem (PDF, 1913 KB)


Polymenidou M*, Prokop S*, Jung HH, Hewer E, Peretz D, Moos R, Tolnay M, Aguzzi A (2011) Atypical prion protein conformation in familial prion disease with PRNP P105T mutation Brain Pathol, 21, 209-14 [*equal contribution] Pubmed linkZora 


Lagier-Tourenne C*, Polymenidou M*, Cleveland DW (2010) TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration Human Mol Gen, 19, R46-64  [*equal contribution]2010 Hum Mol Gen (PDF, 475 KB)


Ilieva H, Polymenidou M, Cleveland DW (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond Journal of Cell Biol, 187, 761-72 2009 J Cell Biol (PDF, 3105 KB)


Xanthopoulos K, Polymenidou M, Bellworthy S, Benestad S, Sklaviadis T (2009) Species and Strain Glycosylation Patterns of PrPSc PLoS One, 4, e5633 2009 PloS One (PDF, 259 KB)


Le Pichon C, Valley M, Polymenidou M, Chesler A, Sagdullaev B, Aguzzi A, Firestein S (2009) Olfactory behavior and physiology are disrupted in prion protein knockout mice  Nature Neurosc,12, 1, 60-9 Nature Neurosci 2009 (PDF, 1378 KB)


Heikenwalder M, Kurrer M, Margalith I, Julius C, Zeller N, Haybaeck J, Polymenidou M, Matter M, Schwarz P, Bremer J, Kranich J, Jackson W, Lindquist S, Sigurdson CJ, Aguzzi A (2008) Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas Immunity 29, 998-1008 Pubmed link 


Polymenidou M, Moos R, Scott M, Sigurdson M, Shi Y-Z, Yajima B, Hafner-Bratkovič I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MNG, Kav N, Aguzzi A (2008) The POM monoclonals a comprehensive set of antibodies to non-overlapping prion protein epitopes PloS One, 3, 12, e3872 2008 PloS One (PDF, 673 KB)


Polymenidou M, Cleveland DW (2008) Motor neuron disease: The curious ways of ALS Nature, 454, 284-5 2008 Nature (PDF, 562 KB)


Kranich J, Krautler NJ, Heinen E, Polymenidou M, Bridel C, Schildknecht A, Huber C, Kosco-Vilbois MH, Zinkernagel R, Miele G, Aguzzi A (2008) Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8 Journal of Exp Med, 205, 6, 1293-302 2008 J Exp Med (PDF, 5742 KB)


Polymenidou M*, Trusheim H*, Stallmach L, Moos R, Julius C, Lenz-Bauer C, Aguzzi A, (2008) Canine MDCK cell lines are refractory to infection with human and mouse prions Vaccine, 26, 2601-14 [*equal contribution] Pubmed link 


Sigurdson CJ*, Nilsson P*, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Aguzzi A (2007) Prion strain discrimination using luminescent conjugated polymers Nature Meth, 4, 1023-30 [*equal contribution]Pubmed link 


Aguzzi A, Heikenwalder M, Polymenidou M (2007)Insights into prion strains and neurotoxicity Nature Rev Mol Cell Biol, 8, 552-61Pubmed link 


Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A (2006) Strain fidelity of chronic wasting disease upon murine adaptation Journal of Virol, 80, 12303-11 2006 J Virol (PDF, 1532 KB)


Sigurdson CJ, Polymenidou M, Aguzzi A (2005) Reconstructing prions: fibril assembly from simple yeast to complex mammals Neurodegenerative Dis, 2, 1-5 Pubmed link  


Polymenidou M*, Stoeck K*, Glatzel M, Vey M, Bellon A, Aguzzi A (2005) Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease Lancet Neurol, 4, 805-14 [*equal contribution] Pubmed link  


Donofrio G*, Heppner FL*, Polymenidou M, Musahl C, Aguzzi A (2005) Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies Journal of Virol, 79, 8330-8338 [*equal contribution] 2005 J Virol (PDF, 484 KB)


Polymenidou M*, Heppner FL*, Pellicioli EC, Urich E, Miele G, Braun N, Wopfner F, Schätzl HM, BecherB, Aguzzi A (2004) Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection PNAS, 101 Suppl 2, 14670-6 [*equal contribution] 2004 PNAS (PDF, 633 KB)


Heikenwalder M*, Polymenidou M*, Junt T, Sigurdson C, Wagner C, Akira S, Zinkernagel R, Aguzzi A (2004) Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration Nature Med, 10, 187-92 [*equal contribution] Pubmed link  


Aguzzi A, Polymenidou M (2004) Mammalian Prion Biology: One Century of Evolving Concepts Cell, 116, 313-27 Pubmed link 


Polymenidou M, Verghese-Nikolakaki S, Groschup M, Chaplin MJ, Stack MJ, Plaitakis A, Sklaviadis T (2002) A short purification process for quantitative isolation of PrPSc from naturally occurring and experimental transmissible spongiform encephalopathies BMC Infect Dis, 2, 23 BMC Infect Dis 2002 (PDF, 374 KB)


Verghese-Nikolakaki S, Michaloudi H, Polymenidou M, Groschup MH, Papadopoulos GC, Sklaviadis T (1999) Expression of the prion protein in the rat forebrain – an immunohistochemical study Neurosc Letters, 272, 9-12 Pubmed link