| 2009 | 2008 | 2007 | 2006 | 2005 > 2001 | 2000 > 1996 | D. Schwinkendorf P. Gallant (2009):  id 202 The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo Gene (2009), 436(1): 90-100 | ABSTRACT | | ZORA | Abstract: Myc proto-oncoproteins are important regulators of growth and proliferation in development. Their functions have been evolutionarily conserved from insects to vertebrates, although the sequence conservation is limited to a few short domains. Here, we analyze the requirement for the most highly conserved domains, called Myc boxes 2 and 3 (MB2 and MB3), and for the weakly conserved N-terminus for the biological activity of the single Drosophila Myc protein in the animal in vivo. We find that a Myc mutant lacking the N-terminus retains very little activity, whereas Myc transgenes carrying a deletion of MB3 have a moderately increased ability to promote growth and apoptosis; mutation of MB2 reduces transcriptional output and the biological activities of Myc. Surprisingly though, Myc without MB2 retains enough activity to partially rescue the lethality of a Myc null mutation. Thus, although MB2 and MB3 are highly conserved in evolution, loss of either domain has comparatively mild consequences on Myc activity in vivo. Peter Gallant (2009):  id 248 Drosophila Myc Advances in Cancer Research (2009), 103(1): 111-144 | ABSTRACT | | ZORA | Peter Gallant Dominik Steiger (2009):  id 257 Myc`s secret life without Max Cell Cycle (2009), 8(23): 3848-3853 | ABSTRACT | | ZORA | __________ imls/literature