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| Stefan Heinzer, Gisela Kuhn, Thomas Krucker, Eric Meyer, AlexandraUlmann-Schuler, Marco Stampanoni, Max Gassmann, Hugo H. Marti, Ralph Müller, Johannes Vogel (2008): |
id 104 |
| Novel three-dimensional analysis tool for vascular trees indicates complete
micro-networks, not single capillaries, as the angiogenic endpoint in mice
overexpressing human VEGF165 in the brain |
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| Eric P. Meyer, Alexandra Ulmann-Schuler, Matthias Staufenbiel, and Thomas Krucker (2008): |
id 125 |
| Altered morphology and 3D architecture of brain
vasculature in a mouse model for Alzheimer’s disease |
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Abstract:
Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer’s disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice have significant blood flow alterations correlated with structural modifications of
blood vessels. For the present study, our objective was to analyze the age-dependent morphological and architectural changes of the cerebral vasculature of APP23 tg mice. To visualize the 3D arrangement
of the entire brain vasculature, we used vascular corrosion casts. Already at young ages, when typically parenchymal amyloid plaques are not yet present, APP23 tg mice had significant alterations, particularly of the microvasculature, often accompanied by small deposits attached to the vessels. In older animals, vasculature abruptly ended at amyloid plaques, resulting in holes. Often, small deposits were sitting near or at the end of truncated vessels. Between such holes, the surrounding vascular array appeared more dense and showed features typical for angiogenesis. We propose that small amyloid aggregates associated with the microvasculature lead to morphological and architectural alterations of the vasculature, resulting in altered local blood flow. The characteristic early onset of vascular alterations suggests that imaging
blood flow and/or vasculature architecture could be used as a tool for early diagnosis of the disease and to monitor therapies. |
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imls/literature
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