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Department of Molecular Life Sciences



Subasic D, Brümmer A, Wu Y, Pinto SM, Imig J, Keller M, Jovanovic M, Lightfoot HL, Nasso S, Götze S, Brunner E, Hall J, Aebersold R, Zavolan M, Hengartner M. Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans. Genome Res. 2015 Jul 31. pii: gr.183160.114. [Epub ahead of print]

Stutz K, Kaech A, Aebi M, Künzler M, Hengartner MO. Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals. PLoS One 2015 Jun 9;10(6) :e0129381. doi: 10.1371/journal.pone.0129381. eCollection 2015.


Sendoel A, Maida S, Zheng X, Teo Y, Stergiou L, Rossi CA, Subasic D, Pinto SM, Kinchen JM, Shi M, Boettcher S, Meyer JN, Manz MG, Bano D, Hengartner MO. DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nat Cell Biol. 2014 Aug;16:812-20.

Sievert H, Pällmann N, Miller KK, Hermans-Borgmeyer I, Venz S, Sendoel A, Preukschas M, Schweizer M, Böttcher S, Janiesch PC, Streichert T, Walther R, Hengartner MO, Manz MG, Brümmendorf TH, Bokemeyer C, Braig M, Hauber J, Duncan KE, Balabanov S. A novel mouse model for inhibition of DOHH mediated hypusine modification reveals crucial function for embryonic development, proliferation and oncogenic transformation. Dis Model Mech. 2014 May 15.

Wohlschlager T, Butschi A, Grassi P, Sutov G, Gauss R, Hauck D, Schmieder SS, Knobel M, Titz A, Dell A, Haslam SM, Hengartner MO, Aebi M, Künzler M. Methylated glycans as conserved targets of animal and fungal innate defense. Proc Natl Acad Sci U S A. 2014 May 30. pii: 201401176. [Epub ahead of print]

Neukomm LJ, Zeng S, Frei AP, Huegli PA, Hengartner MO. Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans. Cell Death Differ. 2014 Jun; 21 :845-53.


Eberhard R, Stergiou L, Hofmann ER, Hofmann J, Haenni S, Teo Y, Furger A, Hengartner MO. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet 2013 Nov;9 :e1003943.

Gysi S, Rhiner C, Flibotte S, Moerman DG, Hengartner MO. A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. PLoS One 2013 Sep 16;8:e74908.

Tholey A, Treitz C, Kussmann M, Bendixen E, Schrimpf SP, Hengartner MO. Model organisms proteomics--from holobionts to human nutrition. Proteomics 2013 Sep;13 2537-41.

Brümmer A, Kishore S, Subasic D, Hengartner M, Zavolan M. Modeling the binding specificity of the RNA-binding protein GLD-1 suggests a function of coding region-located sites in translational repression. RNA 2013 Aug 23.Oct;19 :1317-26.

Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. Mitochondria as a target of environmental toxicants. Toxicol Sci 2013 Jul; 134 , 1-17, Epub 2013 Apr 29.

Snoek LB, Van der Velde KJ, Arends D, Li Y, Beyer A, Elvin M, Fisher J, Hajnal A, Hengartner MO, Poulin GB, Rodriguez M, Schmid T, Schrimpf S, Xue F, Jansen RC, Kammenga JE, Swertz MA.WormQTL--public archive and analysis web portal for natural variation data in Caenorhabditis spp. Nucleic Acids Res 2013 Jan; 41, D738-43, Epub 2012 Nov 24.


Schubert M, Bleuler-Martinez S, Butschi A, Wälti MA, Egloff P, Stutz K, Yan S, Wilson IB, Hengartner MO, Aebi M, Allain FH, Künzler M. Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system. PLoS Pathog 2012 May;8

Haenni S, Ji Z, Hoque M, Rust N, Sharpe H, Eberhard R, Browne C, Hengartner MO, Mellor J, Tian B, Furger A. Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq. Nucleic Acids Res 2012 Jul 1;40:6304-6318. Epub 2012 Mar 29.

Jovanovic M, Reiter L, Clark A, Weiss M, Picotti P, Rehrauer H, Frei A, Neukomm LJ, Kaufman E, Wollscheid B, Simard MJ, Miska EA, Aebersold R, Gerber AP, Hengartner MO. RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans. Genome Res 2012 Jul;22:1360-71

Dittrich CM, Kratz K, Sendoel A, Gruenbaum Y, Jiricny J, Hengartner MO. LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS One 2012;7

Schrimpf SP, von Mering C, Bendixen E, Heazlewood JL, Bumann D, Omenn G, Hengartner MO. The initiative on Model Organism Proteomes (iMOP) Session September 6, 2011, Geneva, Switzerland. Proteomics 2012 Feb;12:346-50.

Jones AM, Aebersold R, Ahrens CH, Apweiler R, Baerenfaller K, Baker M, Bendixen E, Briggs S, Brownridge P, Brunner E, Daube M, Deutsch EW, Grossniklaus U, Heazlewood J, Hengartner MO, Hermjakob H, Jovanovic M, Lawless C, Lochnit G, Martens L, Ravnsborg C, Schrimpf SP, Shim YH, Subasic D, Tholey A, Wijk Kv, Mering Cv, Weiss M, Zheng X. The HUPO initiative on Model Organism Proteomes, iMOP. Proteomics 2012 Feb;12:340-5.

Perini T, Ditzen B, Hengartner M, Ehlert U. Sensation seeking in fathers: the impact on testosterone and paternal investment. Horm Behav. 2012 Feb;61:191-5.

Beyer A, Eberhard R, Piterman N, Hengartner MO, Hajnal A, Fisher J. A Dynamic Physical Model of Cell Migration, Differentiation and Apoptosis in Caenorhabditis elegans. Adv Exp Med Biol 2012 736 :211-33.

Claassen M, Reiter L, Hengartner MO, Buhmann JM, Aebersold R. Generic comparison of protein inference engines. Mol Cell Proteomics 2012 Apr;11


Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. PNAS 2011 Oct 18 108 :17396-401.

Wohlschlager T, Butschi A, Zurfluh K, Vonesch SC, Keller U, Gehrig P, Bleuler-Martinez S, Hengartner MO, Aebi M, Kunzler M: Nematotoxicity of Marasmius Oreades agglutinin (MOA) depends on glycolipid-binding and cysteine protease activity. J Biol Chem 2011 July 8

Bleuler-Martínez S, Butschi A, Garbani M, Wälti MA, Wohlschlager T, Potthoff E, Sabotiĉ J, Pohleven J, Lüthy P, Hengartner MO, Aebi M, Künzler M: A lectin-mediated resistance of higher fungi against predators and parasites. Mol Ecol 2011 Apr 12 [Epub ahead of print]

Almendinger J, Doukoumetzidis K, Kinchen JM, Kaech A, Ravichandran KS, Hengartner MO: A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells. PLoS One 2011, 6:e18325.

Neukomm LJ, Nicot AS, Kinchen JM, Almendinger J, Pinto SM, Zeng S, Doukoumetzidis K, Tronchère H, Payrastre B, Laporte JF, Hengartner MO: The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development 2011, 138:2003-14. Epub 2011 Apr 13.

Reiter L, Rinner O, Picotti P, Hüttenhain R, Beck M, Brusniak MY, Hengartner MO, Aebersold R:mProphet: automated data processing and statistical validation for large-scale SRM experiments.Nat Methods 2011 Mar 20. [Epub ahead of print]

Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe S:Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay.Mol Cell 2011, 41:733-46.

Neukomm LJ, Frei AP, Cabello J, Kinchen JM, Zaidel-Bar R, Ma Z, Haney LB, Hardin J, Ravichandran KS, Moreno S, Hengartner MO:Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.Nat Cell Biol 2011, 13:79-86.


Jovanovic M, Reiter L, Picotti P, Lange V, Bogan E, Hurschler BA, Blenkiron C, Lehrbach NJ, Ding XC, Weiss M, Schrimpf SP, Miska EA, Grosshans H, Aebersold R, Hengartner MO. A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nat Methods 2010, 7:837-42.

Künzler M, Bleuler-Martinez S, Butschi A, Garbani M, Lüthy P, Hengartner MO, Aebi M. Biotoxicity assays for fruiting body lectins and other cytoplasmic proteins. Methods Enzymol. 2010, 480:141-50.

Kratz K, Schöpf B, Kaden S, Sendoel A, Eberhard R, Lademann C, Cannavó E, Sartori AA, Hengartner MO, Jiricny J:Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 2010, 142: 77-88.

Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO :HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 2010, 465: 577-83.

Nieto C, Almendinger J, Gysi S, Gómez-Orte E, Kaech A, Hengartner MO, Schnabel R, Moreno S, Cabello J: ccz-1 mediates the digestion of apoptotic corpses in C. elegans. J Cell Sci 2010, 123: 2001-7.

Cabello J, Neukomm LJ, Günesdogan U, Burkart K, Charette SJ, Lochnit G, Hengartner MO, Schnabel R.: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010, 8: e1000297.

Weiss M, Schrimpf S, Hengartner MO, Lercher MJ, von Mering C: Shotgun proteomics data from multiple organisms reveals remarkable quantitative conservation of the eukaryotic core proteome. Proteomics 2010, 10: 1297-306.

Butschi A, Titz A, Wälti MA, Olieric V, Paschinger K, Nöbauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Künzler M: Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog 2010, 6: e1000717.

Bano D, Hengartner MO, Nicotera P.:Nuclear pore complex during neuronal degeneration: Cracking the last barrier! Nucleus 2010, 1:136-138.


Reiter L, Claassen M, Schrimpf SP, Jovanovic M, Schmidt A, Buhmann JM, Hengartner MO, Aebersold R: Protein identification false discovery rates for very large proteomics data sets generated by tandem mass spectrometry. Mol Cell Proteomics 2009, 8: 2405-17.

Titz A, Butschi A, Henrissat B, Fan Y-Y, Hennet T, Razzazi-Fazeli E, Hengartner MO, Wilson IBH, Künzler M, Aebi M: Molecular basis for galactosylation of core fucose residues in invertebrates: identification of Caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family.  J Biol Chem 2009, 284: 36223-36233.

Schrimpf SP, Weiss M, Reiter L, Ahrens C, Jovanovic M, Malmstroem J, Brunner E, Mohanty S, Lercher MJ, Hunziker PE, Aebersold R, von Mering C, Hengartner MO: Comparative functional analysis of the Caenorhabditis elegans and Drosophila melanogaster proteomes. PLoS Biology 2009, 7:e48.

Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC: Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 2009, 324:381-384.

Tan CSH, Bodenmiller B, Pasculescu A, Jovanovic M, Hengartner M, Jorgensen C, Bader GD, Aebersold R, Pawson T, Linding R: Comparative analysis of protein phosphorylation reveals evolutionary conserved disease networks. Science Signaling 2009,


Kinchen JM, Doukoumetzidis K, Almendinger J, Stergiou L, Tosello-Trampont A, Sifri CD, Hengartner MO, Ravichandran KS: A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol 2008, 10:556-566. top


Lee S, Horn V, Julien E, Liu Y, Wysocka J, Bowerman B, Hengartner MO, Herr W: Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells. PLoS ONE 2007, 2:2279-e1213.

Zermati Y, Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL, Rosselli F, D'Amelio M, Amendola R, Castedo M, Hengartner M, Soria JC, Cecconi F, Kroemer G: Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell 2007, 28:624-637.

Eimer S, Gottschalk A, Hengartner M, Horvitz HR, Richmond J, Schafer WR, Bessereau JL: Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J 2007, 26: 4313-4323.

Züllig S, Neukomm LJ, Jovanovic M, Charette SJ, Lyssenko NN, Halleck MS, Reutelingsperger CP, Schlegel RA, Hengartner MO: Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Curr Biol 2007, 17:994-999.

Taylor RC, Brumatti G, Ito S , Hengartner MO, Derry WB, Martin SJ: Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. J Biol Chem 2007, 282:15011-15021. top


Kritikou E, Milstein S, Vidalain PO, Lettre G, Bogan E, Doukoumetzidis K, Gray P, Chappell TG, Vidal M, Hengartner MO: C. elegans GLA-3 is a novel regulator of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev 2006, 20:2279-2292.

Han SM, Lee TH, Mun JY, Kim MJ, Kritikou E, Lee SJ, Han SS, Hengartner MO, Koo HS: Deleted-in-cancer-1 (DICE-1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans. Development 2006, 133:3597-3606.

Su CW, Tharin S, Jin Y, Wightman B, Spector M, Meili D, Tsung N, Rhiner C, Bourikas D, Stoeckli E, Garriga G, Horvitz HR, Hengartner MO: The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in C. elegans. J Biol 2006, 5:9.

Parusel C, Kritikou EA, Hengartner MO, Krek W, Gotta M: URI-1 is required for DNA stability in C. elegans. Development 2006, 133:621-629. top


Rhiner C, Gysi S, Froehli E, Hengartner MO, Hajnal A: Syndecan regulates cell migration and axon guidance in C. elegans. Development 2005, 132:4621-4633.

Kinchen JM, Cabello J, Klingele D, Wong K, Feichtinger R, Schnabel H, Schnabel R, Hengartner MO: Two pathways converge at CED-10/Rac to mediate actin rearrangement and corpse removal in C. elegans. Nature 2005, 434:393-399.

Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS: A steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr Biol 2005, 15:371-377.

Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann R, Hengartner MO, Schedl T, Gartner A: Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell 2005, 120:357-368.

Zipperlen P, Nairz K, Rimann I, Basler K, Hafen E, Hengartner M, Hajnal A: A universal method for automated gene mapping. Genome Biol 2005, 6:R19. top


Debakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS: Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO. Curr Biol 2004, 14:2208-2216.

Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R: Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing radiation. Nat Genet 2004, 36:906-912.

Lettre G, Kritikou EA, Jaeggi M, Calixto A, Fraser AG, Kamath RS, Ahringer J, Hengartner MO: Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death Differ 2004, 11:1198-1203.

Hoeppner DJ, Spector MS, Ratliff TM, Kinchen JM, Granat S, Lin SC, Bhusri SS, Conradt B, Herman MA, Hengartner MO: eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans. Dev Biol 2004, 274:125-138.

Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran K: PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struc Mol Biol 2004, 11:756-762.

Grimsley CM, Kinchen JM, Tosello-Trampont AC, Brugnera E, Haney LB, Lu M, Chen Q, Schubert D, Klingele D, Hengartner MO, Ravichandran KS: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Bio Chem 2004, 279:6087-6097. top


Hofmann ER, Milstein S, Boulton S, Ye M, Hofmann JJ, Stergiou L, Gartner A, Vidal M, Hengartner MO: C. elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol 2002,12:1908-1918.

Gagnon SN, Hengartner MO, Desnoyers S: The genes pme-1 and pme-2 encode two poly (ADP-ribose) polymerases in Caenorhabditis elegans. Biochem J 2002, 368:263-271.

Harrington RJ, Gutch MJ, Hengartner MO, Tonks NK Chisholm AD: The C. elegans LAR-like Receptor Tyrosine Phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development 2002, 129:2141-2153.

Degtyareva NP, Greenwell P, Hofmann ER, Hengartner MO, Zhang L, Culotti J, Petes TD: C. elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. PNAS 2002, 99:2158-2163. top


Ahmed S, Alpi A, Hengartner MO, Gartner A: C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr Biol 2001, 11:1934-1944.

Gumienny T, Brugnera B, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS: CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 2001, 107:27-41.

Villanueva A, Lozano J, Morales A, Lin X, Deng X, Hengartner MO, Kolesnick RN: jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J 2001, 20:5114-5128.

Hoeppner D, Hengartner MO, Schnabel R: Engulfment genes cooperate with ced-3 to promote cell death in C. elegans. Nature 2001, 421:202-206.

Samuel ADT, Murthy VN, Hengartner MO: Calcium dynamics during fertilization in C. elegans. BMC Dev Biol 2001, 1:8. top


Chung S, Gumienny TL, Hengartner MO, Driscoll M: A common set of engulfment genes mediates the removal of both apoptotic and necrotic cells in C. elegans. Nature Cell Biol 2000, 2:931-937.

Su HP, Brugnera E, Van Criekinge W, Smits E, Hengartner M, Bogaert T, Ravichandran KS: Identification and characterization of a dimerization domain in CED-6, an adaptor protein involved in engulfment of apoptotic cells. J Biol Chem 2000, 275:9542-9549.

Gartner A, Milstein S, Ahmed S, Hodgkin J, Hengartner MO: A conserved checkpoint pathway mediates DNA damage–induced apoptosis and cell cycle arrest in C. elegans. Mol Cell 2000, 5:435-443. top


Liu Q, Hengartner MO: Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr Biol 1999, 9:1347-1350.

Fraser AG, James C, Evan GI, Hengartner MO: Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr Biol 1999, 9:292-301.

Gumienny TL, Lambie E, Hartwieg E, Horvitz HR, Hengartner MO: Genetic control of programmed cell death in the C. elegans germ line. Development 1999, 126:1011-1022.

Liu Y, Hengartner MO, Herr W: Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans. Mol Cell Biol 1999, 19:909-915. top


Liu Q, Hengartner MO: Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell 1998, 93: 961-972.

Lin X, Hengartner MO, Kolesnick R: Caenorhabditis elegans contains two distinct acid sphingomyelinases. J Biol Chem 1998, 273:14374-14379.

Gutch M, Flint A, Keller J, Tonks NK, Hengartner MO: The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev 1998, 12:571-585. top


Lee RYN, Lobel L, Hengartner M, Horvitz HR, Avery L: Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel causes myotonia in Caenorharditis elegans. EMBO J 1997, 20:6066-6076.

Spector MS, Desnoyers S, Hoeppner DJ, Hengartner MO: Direct interaction between C. elegans cell death regulators CED-9 and CED-4. Nature 1997, 385:653-656. top


Metzstein M, Hengartner MO, Tsung N, Ellis RE, Horvitz HR: Transcriptional regulator of programmed cell death encoded by C. elegans gene ces-2. Nature 1996, 382:545-547.

Page AP, MacNiven K, Hengartner MO: Cloning and biochemical characterization of the cyclophilin homologs from the free-living nematode Caenorhabditis elegans. Biochem J 1996, 317:179-186. top


Hengartner MO, Horvitz HR: Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in bcl-2. Nature 1994, 369:318-320.

Hengartner MO, Horvitz HR: C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994, 76:665-676. top


Hengartner MO, Ellis RE, Horvitz HR: Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 1992, 356:494-499.

Thibeault L, Hengartner M, Lagueux J, Poirier GG, Muller S: Rearrangements of the nucleosome structure in chromatin by poly(ADP-ribose). Biochim Biophys Acta 1992, 1121:317-324. top


Huletsky A, de Murcia G, Muller S, Hengartner M, Lamarre D, Poirier GG: The Effects of Poly(ADP-Ribosyl)ation on Native and H1-depleted Chromatin. J Biol Chem 1989, 264:8878-8886.